Lilly drug chosen for Alzheimer's prevention study


Researchers have chosen an experimental drug by Eli Lilly & Co. for a large federally funded study testing whether it's possible to prevent Alzheimer's disease in older people at high risk of developing it.


The drug, called solanezumab (sol-ah-NAYZ-uh-mab), is designed to bind to and help clear the sticky deposits that clog patients' brains.


Earlier studies found it did not help people with moderate to severe Alzheimer's but it showed some promise against milder disease. Researchers think it might work better if given before symptoms start.


"The hope is we can catch people before they decline," which can come 10 years or more after plaques first show up in the brain, said Dr. Reisa Sperling, director of the Alzheimer's center at Brigham and Women's Hospital in Boston.


She will help lead the new study, which will involve 1,000 people ages 70 to 85 whose brain scans show plaque buildup but who do not yet have any symptoms of dementia. They will get monthly infusions of solanezumab or a dummy drug for three years. The main goal will be slowing the rate of cognitive decline. The study will be done at 50 sites in the U.S. and possibly more in Canada, Australia and Europe, Sperling said.


In October, researchers said combined results from two studies of solanezumab suggested it might modestly slow mental decline, especially in patients with mild disease. Taken separately, the studies missed their main goals of significantly slowing the mind-robbing disease or improving activities of daily living.


Those results were not considered good enough to win the drug approval. So in December, Lilly said it would start another large study of it this year to try to confirm the hopeful results seen patients with mild disease. That is separate from the federal study Sperling will head.


About 35 million people worldwide have dementia, and Alzheimer's is the most common type. In the U.S., about 5 million have Alzheimer's. Current medicines such as Aricept and Namenda just temporarily ease symptoms. There is no known cure.


___


Online:


Alzheimer's info: http://www.alzheimers.gov


Alzheimer's Association: http://www.alz.org


___


Follow Marilynn Marchione's coverage at http://twitter.com/MMarchioneAP


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For the record

















































Short films at Sundance: In an article in the Jan. 18 Calendar section about short films at the Sundance Film Festival being shown on YouTube, a second mention of the film "Black Metal" referred to it as "Dark Metal."


California universities: In the Jan. 16 Section A, an article about changes that Gov. Jerry Brown wants in California's public university sytems identified William Tierney as the director of USC's Pelias Center for Higher Education. It is the Pullias Center for Higher Education, not Pelias.


"Life of Pi": In the Jan. 17 edition of The Envelope, a caption for a photograph showing steps in the creation of the movie "Life of Pi" said that a digital framework for the lifeboat was placed over an image of actual water. The water used in those images was also digitally created.







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Sergei Filin, Bolshoi Ballet Director, Is Victim of Acid Attack





MOSCOW – A masked man threw acid in the face of Sergei Filin, the artistic director of the legendary Bolshoi Ballet, on Thursday night, leaving him with third-degree burns and possibly threatening his eyesight, Bolshoi officials said on Friday morning.




The attack followed a series of anonymous threats to Mr. Filin, 42, a dancer who rose through the ranks of the world’s largest ballet company to become its head.


Investigators have not ruled out a dispute over money or property, but are focusing on the theory that Mr. Filin was targeted because of his work, a police spokesman told the Interfax news service.


As dancers kept an overnight vigil at the burn unit where he is being treated, his colleagues said they suspected professional jealousy was behind the attack. In recent weeks, his tires were punctured and his car scratched, and his cellphones and personal e-mail account were hacked and correspondence published, his associates have said. A relative offered to supply Mr. Filin with a bodyguard, but Mr. Filin refused because he did not believe the threats would lead to physical violence, said Dilyara Timergazina, his assistant and adviser.


The threats, she said, “don’t show that someone with great conceptual thinking is behind that, but someone very primitive, with unhealthy aspirations – I don’t know how to put it – someone full of hate.”


Katerina Novikova, the Bolshoi’s press spokeswoman, said that Mr. Filin was opening the gate to his residence when a masked man called out his name and threw the contents of a bottle in his face. After the attack he was able to see out of one eye but not the other, Ms. Timergazina said.


An official at the theater told the Interfax news agency that he would be sent overseas, probably to Germany or Israel, for treatment. Doctors have said his recovery may take as long as six months.


The Bolshoi has a reputation for intrigue and outsized emotions, but Ms. Novikova, the theater’s press secretary, said she never imagined it could lead to violence.


“Sergei was constantly receiving threats after he took up this post and his predecessors were under attack before him,” she told Russia’s Channel One. “We never thought that this war for roles – and not for real estate or for oil – could reach such a criminal level. And we always wanted to believe that people connected with theater would have a minimal level of morality. That’s why this is an absolutely frightening story.”


Mr. Filin signed a five-year contract as director of the Bolshoi in 2011. Among his first big decisions was to hire David Hallberg as a principal dancer – the first American to hold that coveted status, which has traditionally gone to Russian-trained dancers. He suffered a setback when two of its stars, Natalia Osipova and Ivan Vasiliev, left the Bolshoi for a far lesser-known theater in St. Petersburg.


Mr. Filin’s leadership has not stood out as especially controversial. But Anastasia Volochkova, a former Bolshoi ballerina, said his power to assign roles made him the focus of sometimes passionate resentment.


“Sergei didn’t do anything he could be condemned for,” she said, in an interview with Ekho Moskvy, a radio station. “This position is, of course, a sweet one. The head of the ballet decides everything: what grants each artists receive, or maybe won’t receive. Who will dance certain roles, and who won’t dance them.”


She added, “The cruelty of the ballet world has become surprisingly pathological.


One simmering conflict has involved Nikolai Tsiskaridze, a popular principal dancer who last year harshly criticized a recent reconstruction of the theater and has publicly clashed with its leadership since then. A group of Mr. Tsiskaridze’s supporters petitioned President Vladimir V. Putin in November, requesting that Mr. Tsiskaridze be appointed director of the Bolshoi.


Aleksei Ratmansky, Mr. Filin’s predecessor as the company’s artistic director, wrote on Facebook that the incident was “not a coincidence” and wished Mr. Filin “swift recovery and courage.”


Sophia Kishkovsky contributed reporting from the United States.



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Let’s Talk






Hi!


I’m Mark Atwood, and I’m the Director of Open Source Evangelism for HP Cloud Services.  I’ve been working at HPCS for several months now, getting a feel for HP and our place in the open source and OpenStack® community.






I’ve been evangelizing open source for decades, since before “Evangelist” was a technology industry job title, since I was a teenager in high school, when I first read rms’s manifesto in the printed pages of Dr Dobbs magazine. Read more about Let’s Talk »


Linux/Open Source News Headlines – Yahoo! News





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Inspiring Singers Outshine American Idol's Feuding Judges






American Idol










01/17/2013 at 11:00 PM EST







From left: Randy Jackson, Mariah Carey, Ryan Seacrest, Nicki Minaj and Keith Urban


George Holz/FOX


The second episode of American Idol delivered more drama, but a handful of singers managed to eclipse the ongoing feud between new judges Mariah Carey and Nicki Minaj. And that's no easy task considering one of the battling divas is wearing a blonde and pink wig.

The night's most memorable contestant was Lazaro Arbos. As he entered the audition room, one thing became immediately clear: the 21-year-old from Naples, Fla., had a severe stutter. Arbos, who emigrated from Cuba when he was 10, told viewers that he had few friends growing up due to his speech impediment.

But something magical happened when he began to sing. His stutter vanished and he gave a moving performance of "Bridge Over Troubled Water." As the judges unanimously put him through to Hollywood, Arbos dissolved into tears.

Equally inspiring was Mariah Pulice, a 19-year-old restaurant hostess from Darien, Ind. The last two years have been difficult for Pulice, who told judges she was recovering from anorexia. "If there was no music," she said, "I would not be alive." After singing the Beatles' "Let it Be," the judges were unanimous in their praise. "I really, really, really felt that song coming from you," said Minaj.

Carey agreed: "You touched me," she said. "I know what it's like to have to sing through tears. I'm proud of you."

But it wasn't all drama and emotion. Minaj started a baffling trend of asking handsome singers if they had a girlfriend. (She also managed to charm the shirts off of a couple of them, although you get the feeling they were happy to show their abs on national TV.) "You have a hole in your pants," she told one contestant. "Why are you looking?" he shot back.

And poor Keith Urban. Sitting between Minaj and Carey, he found himself in the crossfire. "I feel like a scratching post," he said at one point, before repeatedly banging his head on the table.

The judges found a lot of talent in Chicago. All told, 46 contestants were put through to Hollywood. The competition will head to Charlotte, N.C., next Wednesday.

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Food servers more vulnerable to legal threats


WASHINGTON (AP) — People with severe food allergies have a new tool in their attempt to find menus that fit their diet: federal disabilities law. And that could leave schools, restaurants and anyplace else that serves food more vulnerable to legal challenges over food sensitivities.


A settlement stemming from a lack of gluten-free foods available to students at a Massachusetts university could serve as a precedent for people with other allergies or conditions, including peanut sensitivities or diabetes. Institutions and businesses subject to the Americans With Disabilities Act could be open to lawsuits if they fail to honor requests for accommodations by people with food allergies.


Colleges and universities are especially vulnerable because they know their students and often require them to eat on campus, Eve Hill of the Justice Department's civil rights division says. But a restaurant also could be liable if it blatantly ignored a customer's request for certain foods and caused that person to become ill, though that case might be harder to argue if the customer had just walked in off the street, Hill said.


The settlement with Lesley University, reached last month but drawing little attention, will require the Cambridge, Mass., institution to serve gluten-free foods and make other accommodations for students who have celiac disease. At least one student complained to the federal government after the school would not exempt the student from a meal plan even though the student couldn't eat the food.


"All colleges should heed this settlement and take steps to make accommodations," says Alice Bast, president and founder of the National Foundation for Celiac Awareness. "To our community this is definitely a precedent."


People who suffer from celiac disease don't absorb nutrients well and can get sick from the gluten found in wheat, rye and barley. The illness, which affects around 2 million Americans, causes abdominal pain, bloating and diarrhea, and people who have it can suffer weight loss, fatigue, rashes and other problems. Celiac is a diagnosed illness that is more severe than gluten sensitivity, which some people self-diagnose.


Ten years ago, most people had never heard of celiac disease. But awareness has exploded in recent years, for reasons that aren't entirely clear. Some researchers say it was under-diagnosed, others say it's because people eat more processed wheat products like pastas and baked goods than in past decades, and those items use types of wheat that have a higher gluten content.


Gluten-free diets have expanded beyond those with celiac disease. Millions of people are buying gluten-free foods because they say they make them feel better, even if they don't have a wheat allergy. Americans were expected to spend $7 billion on gluten-free foods last year.


With so many people suddenly concerned with gluten content, colleges and universities have had to make accommodations. Some will allow students to be exempted from meal plans, while others will work with students individually. They may need to do even more now as the federal government is watching.


"These kids don't want to be isolated," Bast says. "Part of the college experience is being social. If you can't even eat in the school cafeteria then you are missing out on a big part of college life."


Under the Justice Department agreement, Lesley University says it will not only provide gluten-free options in its dining hall but also allow students to pre-order, provide a dedicated space for storage and preparation to avoid cross-contamination, train staff about food allergies and pay a $50,000 cash settlement to the affected students.


"We are not saying what the general meal plan has to serve or not," Hill says. "We are saying that when a college has a mandatory meal plan they have to be prepared to make reasonable modifications to that meal plan to accommodate students with disabilities."


The agreement says that food allergies may constitute a disability under the Americans With Disabilities Act, if they are severe enough. The definition was made possible under 2009 amendments to the disability law that allowed for episodic impairments that substantially limit activity.


"By preventing people from eating, they are really preventing them from accessing their educational program," Hill said of the school and its students.


Mary Pat Lohse, the chief of staff and senior adviser to Lesley University's president, says the school has been working with the Justice Department for more than three years to address students' complaints. She says the school has already implemented most parts of the settlement and will continue to update policies to serve students who need gluten-free foods.


"The settlement agreement provides a positive road map for other colleges and universities to follow with regard to accommodating students with food allergies and modifying existing food service plans," Lohse said.


Some say the Justice Department decision goes too far. Hans von Spakovsky, a fellow at the conservative Heritage Foundation who worked in the civil rights division of the Justice Department under President George W. Bush, says food allergies shouldn't apply under the disability act. He adds that the costs could be substantial when schools are already battling backlash from high tuition costs.


"I certainly encourage colleges and universities to work with students on this issue, but the fact that this is a federal case and the Justice Department is going to be deciding what kind of meals could be served in a dining hall is just absurd," he said.


Whether the government is involved or not, schools and other food service establishments are likely to hear from those who want more gluten-free foods. Dhanu Thiyagarajan, a sophomore at the University of Pittsburgh, said she decided to speak up when she arrived at school and lost weight because there were too few gluten-free options in the cafeteria. Like Lesley University, the University of Pittsburgh requires that on-campus students participate in a meal plan.


Thiyagarajan eventually moved off campus so she could cook her own food, but not before starting an organization of students who suffer from wheat allergies like hers. She says she is now working with food service at the school and they have made a lot of progress, though not enough for her to move back on campus.


L. Scott Lissner, the disability coordinator at Ohio State University, says he has seen similar situations at his school, though people with food allergies have not traditionally thought of themselves as disabled. He says schools will eventually have to do more than just exempt students from a meal plan.


"This is an early decision on a growing wave of needs that universities are going to have to address," he said of the Lesley University agreement.


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EPA proposes compromise on Navajo Generating Station's emissions









The Environmental Protection Agency is proposing regulations to reduce emissions from the massive Navajo Generating Station by as much as 84%, in a compromise that would give the plant's operators more time to install scrubbers and would ease the economic impact on two Native American tribes.


Situated in northern Arizona, less than 20 miles from the Grand Canyon, the generating station is the source of haze viewed by tourists at nearly a dozen parks and wilderness areas in the Southwest.


The EPA's proposed rules would allow the 2,250-megawatt plant until 2023 to install pollution controls to meet emissions standards mandated by a Regional Haze Rule. The plant is one of the largest sources of harmful nitrogen oxide emissions in the country, but the agency is proposing to add five years to the compliance date in response to concerns by Navajo and Hopi tribes, EPA Regional Administrator Jared Blumenfeld said.





"It's a deserving compromise, given the real economic threats that face the tribal nations," Blumenfeld said, calling the issue the most complicated he'd ever dealt with. "We wanted to provide enough time to work out the economics so that the facility remains open."


The coal-fired power plant is on land leased from the Navajo Reservation and burns coal mined on both the Navajo and Hopi reservations. The equipment required to bring the plant into emissions compliance would cost an estimated $500 million, and the tribes and a number of groups argued that the economic burden might cause the operators to close the facility, which employs hundreds of tribal members.


The generating station is co-owned by several entities, including the Los Angeles Department of Water and Power.


Blumenfeld said the EPA proposed extending the compliance period also in recognition that the plant's operators had previously installed emission-reducing equipment. When the plant is in compliance, its emissions will total no more than 28,500 tons per year.


"For 90% of the year, the Grand Canyon's air quality is impaired by a veil of pollution haze that reduces the pristine natural visual range by an average of more than 30%," Blumenfeld said in a statement.


National parks and wilderness areas are required to maintain Class I airsheds — the highest level of clear skies. In addition to the Grand Canyon, nearby parks include Zion, Bryce Canyon, Mesa Verde, Arches and Canyonlands.


The plant also provides the power that drives the Central Arizona Project, an expansive aqueduct system that provides water to much of Arizona. State agencies had petitioned the EPA to consider the proposed rules' effect on the cost of water delivery.


The proposed regulations are open to a 90-day comment period.


julie.cart@latimes.com





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Standoff Develops After Militants Seize Hostages in Algeria


Kjetil Alsvik/Statoil, via Reuters


An undated photo of the In Amenas gas field in Algeria, where Islamist militants took at least 20 foreign hostages on Wednesday.







BAMAKO, Mali — As the French military assault on Islamist extremists in Mali escalated into a potentially much broader North African conflict, a tense standoff developed on Thursday between Algerian troops and armed attackers who seized dozens of hostages, including Americans and other foreigners, at an internationally managed gas field in neighboring Algeria and permitted or forced some of them to broadcast their plight.




A French television station, France 24, quoted an unidentified hostage as saying the attackers “were heavily armed and forced several hostages to wear explosives belts. They threatened to blow up the gas field if Algerian forces attempted to enter the site,” the station reported.


The Qatar-based Al Jazeera channel also quoted a hostage identified as British as saying the hostages were “receiving care and good treatment from the kidnappers” but Algerian forces surrounding the installations were “firing at the camp.”


Both stations said it was unclear whether the people they interviewed had been speaking under duress. Al Jazeera quoted a kidnapper as demanding that the Algerian Army pull back to permit negotiations to end the crisis.


Apart from foreign hostages, said by the attackers to number 41, a large number of Algerians were also seized, but the Algerian news agency reported on Thursday that 30 of them had escaped.


Algerian officials said at least two people, including a Briton, were killed in the assault, which began with an ambush on a bus trying to ferry gas-field workers to an airport and was depicted by the attackers as reprisal for the French intervention in Mali and also to punish Algeria for allowing French warplanes to use its airspace to reach targets in northern Mali.


The British Foreign Office confirmed that a British citizen had been killed in the attack but a spokeswoman declined to give details or identify the victim. Foreign Secretary William Hague said the hostages included "a number of British nationals. This is therefore an extremely dangerous situation."


Hundreds of Algerian security forces surrounded the gas-field compound and the country’s interior minister said there would be no negotiations.


Algeria’s official news agency said at least 20 fighters had carried out the attack and mass abduction. There were unconfirmed reports late on Wednesday that the security forces had tried to storm the compound and had retreated under gunfire from the hostage takers.


Many details of the assault on the gas field in a barren desert site near Libya’s border remained murky, including the precise number of hostages. American, French, British, Japanese and Norwegian citizens who worked at the field were known to be among them, officials said.


Defense Secretary Leon E. Panetta called the gas-field attack a terrorist act and said the United States was weighing a response. His statement suggested that the Obama administration could be drawn into a military entanglement in North Africa that it had been seeking to keep at arm’s length — even as it has conceded that the region has become a new haven for extremists who threaten Western security and vital interests.


“I want to assure the American people that the United States will take all necessary and proper steps that are required to deal with this situation,” Mr. Panetta said during a visit to Italy.


The gas-field attack, which seemed to take foreign governments and the British and Norwegian companies that help run the facility completely by surprise, appeared to make good on a pledge by the Islamist militants who seized northern Mali last year to sharply expand their struggle against the West in response to France’s military intervention that began last week.


The hostage taking broadened the conflict beyond Mali’s borders and raised the possibility of drawing an increasing number of foreign countries into direct involvement, particularly if expatriates working in the vast energy extraction industries of North Africa become targets. It also doubled, at least, the number of non-African hostages that Islamist militants in northern and western Africa have been using as bargaining chips to finance themselves in recent years through ransoms that have totaled millions of dollars.


But there was no indication that the gas-field attackers wanted money, and no other demands or ultimatums were issued. In a statement sent to ANI, a Mauritanian news agency, they demanded the “immediate halt of the aggression against our own in Mali.”


Adam Nossiter reported from Bamako, and Scott Sayare and Alan Cowell from Paris. Reporting was contributed by Clifford Krauss from Houston, Rick Gladstone from New York, Elisabeth Bumiller from Rome, and Steven Erlanger from Paris.



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You Can Use Facebook for Free Cellphone Calls Now






Wait, what?


RELATED: Facebook’s Faster iPhone App Isn’t Fast Enough






Yes, theoretically you can kis those talk-time minutes from your cellphone data plan goodbye — as long as you’re content to have all your voice conversation with other Facebook users over data or Wi-Fi by way of your Messenger app. It’s called Voice Over Internet Protocol talking, and it’s the same thing that was supposed to help Skype take over the world last decade, and it might end up being a lot more useful to the savvy consumer’s pocketbook than the Graph Search, which Mark Zuckerberg called the “third pillar” of Facebook yesterday.


RELATED: Everything There Is to Know About That Facebook Phone


To make a call, all Facebook users have to do is tap the little “i” at the top right corner of the revamped app, which leads to the screen pictured above at right. As long as the other caller has the Messenger app, U.S. users can now tap Free Call, and, well, it’s just like making a phone call, really — except that instead of ringing, a push notification pops up: “You have a call from Carly.” (Seriously! We just tried it! It was free!)


RELATED: What Can Apple’s Acquisition of Chomp Mean?


Of course, this isn’t a Facebook-branded piece of hardware, or even the full-scale cellphone OS many have been drooling over as the social network figures out its mobile future. But this software could replace the traditional way we make calls. As we’ve explained before, Facebook has a lot of things going for it in taking VoIP calls to the masses in the way the Skype never really could: Messenger’s got all the right contacts, it costs almost nothing, and it even works in areas with terrible reception. Not to mention it works over data plans for everyone and not just people with compatible phones — Apple’s FaceTime feature only works on the iPhone 4S or 5, even if it’s more available now. Still, Facebook doesn’t have video chat for Messenger. But, hey, one world dominating step at a time, right?


Social Media News Headlines – Yahoo! News





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American Idol's New Judges Make Their Debut






American Idol










01/16/2013 at 11:00 PM EST







From left: Randy Jackson, Mariah Carey, Ryan Seacrest, Nicki Minaj and Keith Urban


Michael Becker/FOX.


American Idol is back!

Season 12 premiered Wednesday night with the first auditions in New York City. And fans hoping to get a taste of drama from new judges Mariah Carey and Nicki Minaj were not disappointed.

"Right away we knew it was going to be an interesting couple of days," host Ryan Seacrest said at the start of the two-hour episode.

And he was right. (Spoilers ahead!) While fellow newbie Keith Urban and veteran judge Randy Jackson were all about the business of finding talented singers, there was immediate tension between Carey and Minaj, who wore a drum major's hat to her first day on the job.

"We can have accessories?" Carey said disapprovingly after taking her seat at the panel. "I didn't know that was allowed."

"Why did you have to reference my hat?" Minaj responded.

Later, when Carey boasted about her holiday hit, "All I Want for Christmas," Minaj clenched her fists, gritted her teeth and used the b-word. Carey's response? "I rebuke it," she said.

The two women talked over each other at times, rolled eyes and seemed to annoy one another. More than once Carey said "Nicki" like an frustrated mother calls her child out for misbehaving. And Minaj pushed Carey's buttons by talking in a British accent.

But as the two formerly feuding judges have said in recent interviews, the show should be about the hopeful contestants – and there were a handful of talented singers who earned golden tickets to Hollywood:

• Tenna Torres, who attended Camp Mariah and had previously sung for the singer, impressed the panel with her version of "You've Got a Friend," and made her idol very proud.

• Christina "Isabelle," who told a story of losing weight and finding confidence, had Minaj saying, "OMG! OMG!" with her version of "Summertime."

• Frankie Ford, who sings for change on the New York City subway system, stumbled at first but delivered a soulful version of the Eurythmics' "Sweet Dreams." "I like your big voice," Urban said. "There's a lot of musicality in the tone."

Added Carey: "You have an inner glow, which is always beautiful to see."

• Despite hearing loss in both ears, Angela Miller, who sang "Mama Knows Best" by Jessie J, was "definitely one of the best," according to Jackson.

• And Ashlee Feliciano thrilled the female judges with her version of Corinne Bailey Rae's "Put Your Records On." "So pretty," Minaj said. "I want to come to your show ... I'm so inspired by you."

"The potential is great. It was beautiful," Carey said. "You should be really proud of yourself."

At the end of the first two days of auditions, the re-invented Idol panel had done its job: the judges praised the talented singers and handed out 41 tickets to Hollywood; they sent home the kooky contestants (often sweetly) and offered constructive criticism and an invitation to come back next year to the ones still on their way to greatness.

"We gel well in a weird crazy way," Minaj said at the end of the show. Carey said, "I agree."

We'll see how long that lasts! Auditions continue Thursday (8 p.m. ET) on Fox.

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